Dissolution profile of Curcumin from solid dispersion prepared at a high drug load of Curcumin using Poloxamer 407 as the carrier

Introduction: Curcumin, a BCS II drug, suffers from poor bioavailability. Increasing curcumin dissolution is way to increase its Solid dispersion formulation can be used improve dissolution. However, the successful solid limited relatively low drug load (< 20%). Aim: This study aimed investigate behaviour of at higher (27.9%, 42.3%, and 56.6%) using surfactant carrier poloxamer 407. Methods: The solvent evaporation method was employed prepare high curcumin. A physical mixture corresponding prepared as control. Drug load, in 180 minutes, efficiency (DE180) were determined. Results: results showed that incorporating into 407 significantly improves rate In formula, found carrier-dependent.